Combined Sinus Grafting and Lateral Augmentation by a Hyaluronic Acid-Facilitated Guided Bone Regeneration Protocol – Case Series Supported by Human Histologic Analysis

Guided Bone Regeneration (GBR) is a well-established procedure for the regeneration of alveolar bone defects. In case highly complex defect situations, however, inconsistent treatment results are often achieved. Hyaluronic Acid (HA) fulfills several relevant preliminary success criteria improved regenerative outcomes in defects: HA supports creation toxin-free wound area, improves space stabilization, accelerates healing and processes crucial regeneration. The novelty reported cases use porcine derived substitute particulate hydrated with cross-linked hyaluronic acid simultaneous sinus grafting lateral/vertical ridge augmentation combination ribose collagen membrane. approval feasibility provided clinical histological observations. Three consecutive received abovementioned material staged floor elevation additional by one operator according to standardized protocol. All three sites constantly demonstrate superior terms radiographically impressive tissue enhancement implant function. supported qualitative analysis reflecting great similarity between samples regarding observed process new formation behavior. specific staining allows detection osteoclastic activity indicates tendency degrade over time once integrated.